The reason why they also lead to weight loss is that they work on the centers of appetite and satiety in our central nervous system to tell us we’re fuller faster, and they slow down gastric motility, she adds. “When glucose is high, they lower blood sugar glucose by enhancing insulin release,” Dr. First, they work by signaling the pancreas to release insulin. These drugs use a few different mechanisms to treat diabetes. Mounjaro is currently approved for blood-sugar control in people with type 2 diabetes, with the FDA stating that is “more effective than the other diabetes therapies with which it was compared in clinical studies. “The newest kid on the block is Mounjaro, or tirzepatide, which has been fast-tracked by the FDA for obesity management,” Dr Rothberg adds. There are more meds like this coming down the pike. Elon Musk tweeted that he had used Wegovy, setting off yet another controversy over whether the tech mogul might be using the drug off-label for reasons of vanity rather than health. In 2021, Wegovy, which contains the same active ingredient as Ozempic but in an even higher dose (2.4 mg ), was FDA-approved specifically to treat adults with obesity or who were overweight and had at least one weight-related condition, such as high blood pressure, high cholesterol or type 2 diabetes. A year later, in 2022, the FDA approved a higher dose version of Ozempic, which is now available in both 1mg and 2mg versions. It was quickly noted, however, that the drug also led to significant weight loss, and in 2021, the FDA approved Ozempic to treat obesity. Ozempic is injected once a week in the stomach, thigh or upper arm, and in trials, up to 73% of people with type 2 diabetes lowered their blood sugar after using the drug. This story begins in 2017, when the FDA gave the green light to Ozempic, an injectable drug that contains the active ingredient semaglutide: “Ozempic was first approved and indicated for the management of type 2 diabetes,” explains Amy Rothberg, MD, a clinical professor of internal medicine at University of Michigan Health and spokesperson for the Endocrine Society. However, many basic facts about the medication, who should be taking it, and, yes, how exactly it can affect your face have been lost in the shuffle. Kim hasn't confirmed whether she took Ozempic or any other medication to help with weight loss, but since then, the drug gained major hype. Play icon The triangle icon that indicates to play Whispers about “Ozempic face” - a hollowed-out, loose-skinned, droopy appearance, due to losing weight quickly with the drug - first started swirling when Kim Kardashian appeared in public with “a more sculpted, less volumized face,” says Jennifer Levine, MD, a New York facial plastic surgeon who has treated many patients (not Kim) whose faces have lost fat and elasticity when they've lost weight quickly.
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Unless you have type 2 diabetes or have been prescribed medication to treat obesity plus other chronic conditions, you may have only heard the name Ozempic from those ubiquitous commercials: “Oh, oh, oh, oh-ZEM-pic” sung to the tune of '70s hit “It's Magic.” But in the last few weeks, the phrase #OzempicFace has been viewed half a million times on TikTok, and the Times published a report on the topic, complete with haunting illustration of what looks like a weirdly distorted Phantom of the Opera mask. When TikTok and the New York Times are both abuzz about a very 2023 phenomenon known as "Ozempic face," you know it has reached maximum social impact.
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